| Positions | Details | Years |
|---|---|---|
| Freelance Data Scientist & Computational Biologist (Current Position). | Dedicating my time to Personal Development, family care, profile up-scaling and to pursue entrepreneurial opportunities. Completed online courses on Statistics, Machine Learning, Dashboard Skills, MySQL Skills and Web Development. As part of entrepreneurial training I attended multiple courses on local business development. | October 2023 to current |
| Data Scientist at Creme Global. | Data Scientist at Creme Global. | April 2023 to Sept 2023. |
| Statistician and Quality Engineering Abbott Ireland. | Provide Statistical and Data Analytics support to Technical Operations. Also support other operations associated with Diagnostics manufacturing. | 2022 to 2023 |
| Research Fellow at University College Dublin. | I joined UCD in 2019 as a Marie Skłodowska-Curie Caree-FIT Fellow and my fellowship is funded by European Union’s Horizon2020 research and innovation programme under Marie Skłodowska-Curie Caree-FIT grant. The area of my research project is: characterising proteolysis and developing software/webserver for the analysis of proteolysis data obtained from food digestion. In this project, as an industrial secondment, I worked with Carbery Group, Cork, Ireland. | 2019 to 2022 |
| Research Fellow at Institute of Molecular and Cell Biology A*STAR Singapore. | I was involved with NGS data analysis for various projects. Expression of a specific set of long non-coding RNAs and their influence on molecular regulation of inflammation was one of them. NFkB orchestrated regulation of various inflammatory pathways were also included in the area of work. Beside working with the academic workflow, I was also involved with PuRPOSE program, which was an industry-academic collaborative platform for providing precision medicine service to liver cancer patients. | 2018 |
| Research Fellow at Academy of Immunology and Microbiology POSTECH South Korea. | I did computational genomics to understand the relation between immunity and immunomodulatory components. I was also involved in performing comparative genomics and metagenonmics analysis to investigate various aspect of probiotics. Key areas & expertise earned from this job: NGS data analysis, Metagenomics analysis, T-cell repertoire analysis, Regulatory genomics mining tools, Genome annotation. | 2017 to 2018 |
| Postdoctoral Researcher (Research Professor) at School of Medicine Sungkyunkwan University, South Korea. | I did docking, virtual screening and molecular dynamics simulation for in silico small-molecule and peptides based drug discovery. I was also involved in doing motif prediction, cancer genomics and NGS data analysis to solve interesting research problems related to the role of regulatory mutations in cancer genomics. Performed extensive communication and collaboration with more than five experimental research groups. Actively participated in design and implementation of theories/predictions for experimental projects. Involved in handling super-computer node at DGIST (Daegu Gyeongbuk Institute of Science and Technology) and CUDA-core based molecular dynamics simulation in GROMACS. Role of account administrator of Sungkyunkwan University for the NCBI eRA-dbGAP account including TCGA/GDC cancer genome database.Extensive shell scripting and Python scripting for handling regex based prediction of motifs and other genomics pipelines. Key areas & expertise learned are: Protein & DNA motif prediction, MD simulation (GROMACS), Protein homology modeling, Cancer genomics (patient sample data), Shell Scripting, Python, Software used: Discovery Studio, MOE. OS: Ubuntu 12.04 LTS | 2014 to 2017 |
| Research Associate at C&MB Division SINP , Kolkata, India. | I did comparative genomics, druggable genome mining, pharmacophore modelling and virtual screening to repurpose and develop drug against parasite Leishmania sp. Besides, I also gained hands on experience in the process of crystallizing a drug-target protein of Leishmania sp. named Fructose-1-6-bisphosphatase. Performed experimental work on protein crystallography beside computational research. Actively participated in designing and execution of the project. Published papers on motif prediction by making independent collaboration Clinical Bioinformatics group of UCD, Ireland. Worked and parasitic disease model : Leishmania sp. Wrote small codes in C/C++ to handling output of comparative genomics data. Handled plenty of protein and small molecule structures in-silico for structural bioinformatics. Key areas & expertise: Pharmacophore design (Discovery Studio, Pharmer & Ligand Scount), Docking (GOLD), Protein Modeling (Modeller), Protein purification, Drug repurposing, Quantum chemical theory based small molecule energy minimization (GAMESS). | 2012 to 2014 |
| PhD Student at Physics Department, Jadavpur University, Kolkata, India. | I worked on developing algorithm for numerical characterization and phylogenetic analysis of proteins and peptides. Besides, I was also involved with characterizing druggable surface region of pathogen's target proteins, epitope discovery and peptide vaccine design. Performed extensive collaboration with theoritical physicists to develop algorithm. Worked on disease moedel/protein: Influenza virus & Rota virus. Worked & gained lot of experiences on genome, mutational landscape and drug design field on Influenza Virus. Also did collaboration with interanational researcher and wet-lab experimental researcher to develop idea and published papers. Published papers in corresponding authors and wrote an invited book chapter. Gained lots of teaching experiences by taking class in three different colleges as guest lecturer. Key areas & expertise: Sequence Alignment, Epitope prediction, Vaccine discovery approaches, Microsoft Excel, Phylogenetic tree drawing algorithms, Protein modelling, Mutation analyses . | 2007 to 2012 |
Ghosh, A., et al. (2009). "Computational study of dispersion and extent of mutated and duplicated sequences of the H5N1 influenza neuraminidase over the period 1997− 2008." Journal of chemical information and modeling 49(11): 2627-2638. link
Nandy, A., et al. (2009). "Numerical characterization of protein sequences and application to voltage-gated sodium channel α subunit phylogeny." In silico biology 9(3): 77-87. link
Ghosh, A., et al. (2010). "A STUDY ON PORE FORMATION DYNAMICS IN BIO-MIMICKING MEMBRANE SYSTEM." Romanian Journal of Biophysics 20(4): 347-354. link
Ghosh, A., et al. (2010). "Computational analysis and determination of a highly conserved surface exposed segment in H5N1 avian flu and H1N1 swine flu neuraminidase." BMC Structural Biology 10(1): 6. link
GHOSH, A. and A. NANDY (2011). "Graphical representation and mathematical characterization of protein sequences and applications to viral proteins." Advances in protein chemistry and structural biology 83: 1. link
Ghosh, A., et al. (2012). "In Silico Study of Rotavirus VP7 Surface Accessible Conserved Regions for Antiviral Drug/Vaccine Design." PLoS ONE 7(7): e40749. link
Ruhanen, H., et al. (2014). "Potential of known and short prokaryotic protein motifs as a basis for novel peptide-based antibacterial therapeutics: a computational survey." Frontiers in Microbiology 5: 4. link
Waugh, B., et al. (2014). "In silico work flow for scaffold hopping in Leishmania." BMC research notes 7(1): 802. link
Hur, J., et al. (2016). "Design of a RANK-Mimetic Peptide Inhibitor of Osteoclastogenesis with Enhanced RANKL-Binding Affinity." Molecules and Cells 2016(39(4)). link
Nguyen, T., et al. (2016). "An ubiquitin-binding molecule can work as an inhibitor of ubiquitin processing enzymes and ubiquitin receptors." Biochemical and biophysical research communications 479(1): 33-39. link
Jung, H., et al. (2017). "The mutational landscape of ocular marginal zone lymphoma identifies frequent alterations in TNFAIP3 followed by mutations in TBL1XR1 and CREBBP." Oncotarget. link
Kim, C. J., et al. (2018). "The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus." Immunity 49(6). link
Ravichandran, S., et al. (2018). "Genome-wide analysis of regulatory G-quadruplexes affecting gene expression in human cytomegalovirus." PLoS Pathogen. link
Verma, R., et al. (2018). "Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T cells." Science Immunology 3(28). link
Chattopadhyay, C., et al. (2021). "RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and initiates a novel mRNA decay pathway." bioRxiv. link
Bala, S., et al. (2021). "Web application Development for Protein Segment Variability Analysis." VIZBI 2021 Conference, Visualizing Biological Data. link
Bala, S., et al. (2021). "Development of Web Application for the Comparison of Segment Variability with Sequence Evolution and Immunogenic Properties for Highly Variable Proteins: An Application to Viruses." bioRxiv. link
Ghosh, A., et al. (2021). "Estimation of Exoproteolysis from Mass Spectrometry Data Using Analysis of Staircase Patterns." Great Lakes Bioinformatics Conference 2021, May 10-13, 2021. link
Hur, J. H., et al. (2021). "AC-motif: a DNA motif containing adenine and cytosine repeat plays a role in gene regulation." Nucleic Acid Research 49(17). link
Rvichandran, S., et al. (2021). "The effect of hairpin loop on the structure and gene expression activity of the long-loop G-quadruplex." Nucleic Acid Research 49(18). link
Ovung, A., et al. (2022). "Heme Protein Binding of Sulfonamide Compounds: A Correlation Study by Spectroscopic, Calorimetric, and Computational Methods" ACS Omega 6(4932-4944). link
My skills are focused around theories and knowledge of biology. I did my bachelor and master degree in pure biological sciences and from my PhD I started to develop skills in computational biology. Over the years I have gained both programming and biological data analysis skills. Let me present my skillls in a better way in this page.
In a overview, domains of my certificates covers mainly academic and few industrial credentials. In addition, recently I am developing new skills in web application development and software development in computational biology, which encouraged me to do certifications in different programming languages & related tools. Some of the important certificates include the areas like: Lean Six Sigma Training, Project Management Training, etc. etc. All my certificates are listed or will be added to my LinkedIn profile.